Welcome to MPCA!

Citation

If this website is useful to you, please consider citing Xiao et al. (2025) Nature. doi: https://doi.org/10.1038/s41586-025-09535-5

Protein-metabolite Pearson Correlations:

Search a protein-metabolite edge for correlation statistics

Correlation Statistics:

Pearson Plot:

Search a protein or metabolite for top correlators

All Correlates

Positive edges in red. Negative edges in blue.

Postive correlators (Ranked):

Negative correlators (Ranked):

Pathway/Reaction Recapitulations

Search for significant protein-metabolite correlations recapitulating established biochemical reactions, metabolite-transporter relationships, and pathways from Rhea, TCDB, and Reactome.

All pathways and reactions

TCDB

The database details a comprehensive IUBMB approved classification system for membrane transport proteins known as the Transporter Classification (TC) system. The TC system is analogous to the Enzyme Commission (EC) system for classification of enzymes, except that it incorporates both functional and phylogenetic information. Curated annotations, TC numbers, and external references for 1922 families of transport proteins are provided. Transport systems are classified on the basis of five criteria, and each of these criteria corresponds to one of the five numbers or letters within the TC accession for a particular type of transporter.

Reactome

REACTOME is an open-source, open access, manually curated and peer-reviewed pathway database. Our goal is to provide intuitive bioinformatics tools for the visualization, interpretation and analysis of pathway knowledge to support basic and clinical research, genome analysis, modeling, systems biology and education. Founded in 2003, the Reactome project is led by Lincoln Stein of OICR, Peter D’Eustachio of NYU Langone Health, Henning Hermjakob of EMBL-EBI, and Guanming Wu of OHSU.

Rhea

Rhea is an expert-curated knowledgebase of chemical and transport reactions of biological interest - and the standard for enzyme and transporter annotation in UniProtKB. Rhea uses the chemical dictionary ChEBI (Chemical Entities of Biological Interest) to describe reaction participants.

note: rows with empty statistical values indicates it was not recapitulated in the database.

Swipe for all columns

Pathway/Reaction Interactive

Full reaction network: Metabolite nodes in purple. Protein nodes in green. Positive recapitulated edges in red. Negative recapitulated edges in blue. Hover over protein nodes for more info.
Select a row in the table to see reaction/pathway.
Full reaction network: Metabolite nodes in purple. Protein nodes in green. Positive recapitulated edges in red. Negative recapitulated edges in blue. Hover over protein nodes for more info.

Protein predictors of metabolite abundance

Search a protein or metabolite:

Mitochondrial proteins are colored in pink. Transporter proteins are colored in blue. Metabolic proteins are colored in yellow.
 Extreme outliers are colored in red Unspecified proteins are colored in grey.
Proteins that are classified more than once are colored as the overlap between the categories.

Search for a metabolite:

Zoom out to see all metabolites.

Single Analyte Search

Protein/Metabolite Abundance

Coefficient of Variation Density Plot

Bulk download data files

Pearson Correlation Files:

BAT (csv) Liver (csv)

Database Recapitulation Files:

Rhea BAT (csv) Reactome BAT (csv) TCDB BAT (csv) Rhea Liver (csv) Reactome Liver (csv) TCDB Liver (csv)

Machine Learning Metabolite Lists:

BAT (csv) Liver (csv)

Acknowledgements

this is the content of the acknowledgements tab